Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation
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چکیده
منابع مشابه
Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation
Neutrophils are widely recognized to play an important role in acute inflammatory responses, and recent evidence has expanded their role to modulating chronic inflammatory and autoimmune diseases. Reactive oxygen species (ROS) and microbicidal compounds released from neutrophils that are recruited to the site of inflammation contribute to the pathogenesis of multiple inflammation-associated dis...
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Cell migration is fundamental to the inflammatory response, but uncontrolled cell migration and excess recruitment of neutrophils and other leukocytes can cause damage to the tissue. Here we describe the use of an in vivo model - the Tg(mpx:GFP)(i114) zebrafish line, in which neutrophils are labelled by green fluorescent protein (GFP) - to screen a natural product library for compounds that can...
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A systematic search for constituents of marine sponges has yielded over one hundred new compounds, most of them with unique structural features. A broad survey of the field is presented and certain topics, particularly those closely related to recent work done in our own laboratory on sesquiterpenoids, are discussed in more detail.
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In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relationship was preliminarily studied. Compounds 19 and 20 are potent P-gp inhibitors. These two synthetic analogues of permethyl ningalin B may be pot...
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ژورنال
عنوان ژورنال: Marine Drugs
سال: 2016
ISSN: 1660-3397
DOI: 10.3390/md14080141